Cannabis, heart disease, and a soy-derived supplement that may help

Today, the cannabis industry is worth over a trillion dollars. Yet, CannaMD converts plant-based cannabinoids into pharmaceuticals that are being used to treat conditions like cancer and epilepsy alongside heart disease and pain management. Their latest product targets COPD which can lead to severe respiratory distress for patients with chronic obstructive pulmonary disorder (COPD). While CBD has proven effective in treating symptoms of this condition when combined with other natural compounds such as eucalyptus oil and menthol, it doesn’t have any long-term effects on

The “can cbd cause arrhythmia” is a question that has been asked for a while. Cannabis, heart disease, and a soy-derived supplement that may help are the three topics discussed in this article.

Cannabis, heart disease, and a soy-derived supplement that may help

Cannabis-heart-disease-and-a-soy-derived-supplement-that-may-help

 

The health effects of cannabis are currently being researched. Cannabis derivatives may provide several health advantages. Researchers are still figuring out how to combine these benefits with possible health dangers.

A recent investigation In a study published in the journal Cell, Trusted Source looked into the negative cardiovascular effects of cannabis and discovered that it has a particularly negative influence on cardiovascular health.

However, the substance genistein was discovered to help reduce these negative effects by the researchers.

Cannabis usage is growing in popularity, particularly for recreational uses. However, researchers are still working to uncover all of cannabis’ therapeutic advantages.

Tetrahydrocannabinol (THC) is the chemical in cannabis that causes mind changes and reduced mental performance, according to the US Centers for Disease Control and PreventionTrusted Source. Delta-9-tetrahydrocannabinol is the primary ingredient that produces these effects (delta-9-THC). Cannabis’ cannabidiol (CBD) ingredient, on the other hand, does not produce this kind of impairment.

The usage of Epidiolex, which includes CBD, has been authorized by the United States Food and Drug Administration (FDA). This medication may be used to treat seizures. Marinol and Syndros, two synthetic THC drugs, have also been authorized by the FDA. Both of these drugs may reduce nausea and increase appetite.

Cannabis, in addition to its advantages, has been connected to health risksTrusted Source. The possible link between cannabis and cardiovascular issues is one area of special attention.

When approached for response, Paul Armentano, deputy director of the National Organization for the Reform of Marijuana Laws (NORML), pointed out that several research on the influence of cannabis on cardiovascular health have shown mixed findings. To Medical News Today, he explained:

“Historically, population-based studies examining the possible relationship between cannabis consumption and cardiovascular risks have produced notoriously conflicting findings… NORML has long advised care with regard to cannabis exposure among persons with a history of heart disease or other cardiovascular difficulties, as well as other possibly higher-risk demographics, due to a lack of reliable research.”

As a result, additional study in this area is required.

This was the goal of the research in question. The U.K. Biobank, “the biggest prospective cohort research to date, collecting genetic and phenotypic data on 500,000 people ages 40-69,” was used to investigate the link between cannabis usage and heart attacks.

Cannabis consumption was linked to a greater risk of heart attack based on the analysis of this data.

Participants who used cannabis recreationally were also recruited by the researchers. They discovered that after smoking a cannabis cigarette, these people had higher levels of inflammatory cytokines, suggesting an increased risk of atherosclerosis.

The researchers next looked at the effects of delta-9-THC on endothelial cells, which make up the cardiovascular system. Delta-9-THC was discovered to promote oxidative stress and inflammation, both of which impair the cardiovascular system.

They also observed that delta-9-THC produced vascular impairment in mouse models. According to their findings, delta-9-THC may harm the cardiovascular system.

A natural supplement that might be beneficial

The researchers used the soybean-derived chemical genistein to prevent these effects. They discovered that it aided in the reduction of the effects of inflammation and oxidative stress on the cardiovascular system.

In mice models of atherosclerosis, they observed that genistein reduced the severity of the disease.

Dr. Joseph Wu, head of the Stanford Cardiovascular Institute and professor of cardiovascular medicine and radiology, told MNT about the study’s highlights:

“Based on the U.K. biobank, stem cell-derived vascular cells, and mice models, our work reveals that marijuana (cannabis) is associated to cardiovascular disease.” We have discovered a naturally occurring soybean derivative, genistein, that can be utilized to counteract the negative effects of marijuana on the cardiovascular system, thanks to machine learning.”

There were various flaws in the research. To begin with, the researchers were unable to establish a link between cannabis usage and heart attacks. They recognize that the data from the UK Biobank cohort might have problems.

Because the research employed mice as a model, any conclusions drawn about humans should be interpreted with care.

According to Armentano, the study may fall short in terms of research consistency in the field.

“This current article is only the latest in a long line of contradictory findings — findings that are likely to differ depending on how thoroughly investigators control for possible confounding factors and behaviors among individuals.”

He did point out, however, that the researchers’ theory, based on results from their mouse studies, that it could be “due to cannabinoids triggering inflammation of the blood vessels and thus atherosclerosis is inconsistent with human observational studies,” was “inconsistent with human observational studies.”

Nonetheless, the findings suggested that genistein might help minimize some of cannabis’s potentially hazardous effects while preserving some of its favorable ones.

“[g]enistein, a soybean isoflavone, prevents adverse cardiovascular effects of [delta-9-THC] while preserving therapeutically helpful benefits including drowsiness and analgesia,” the study authors said.

MNT spoke with study author Joseph Wu on the direction of future research in this area:

“While preclinical models have indicated that genistein may inhibit the negative effects of marijuana on the cardiovascular system, a randomized clinical study to assess its safety and efficacy in people is required.”

“Genistein might also be a novel lead molecule that leads to the creation of new cardiovascular disease medications,” Wu noted.

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